Nandini Sarkar

Assistant Professor Grade-I

Biotechnology and Medical Engineering

 (+91) 661 246 2293 , 3293






Sponsored Projects


Consultancy Projects


Doctoral Students


Continuing Education


PG Dissertation

 Personal Information

Prof. Nandini Sarkar

Assistant Professor Grade-I

Biotechnology and Medical Engineering

Joined in Aug 2011

 Room Number: BM-215

 Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Sundargarh, Odisha, India - 769008

 Education Qualification

  1. Ph.D.
    Studies on effect of small molecules on protein folding, misfolding and amyloidogenesis
    Indian Institute of Technology Guwahati


Teaching Experience
  • Biotechnology,  NIT Rourkela,  29 Aug 2011 - Present

 Expertise Information

Research Group
Cell and Molecular Engineering
Areas of Interest
Structure-function of proteins, Protein Biochemistry, Structural biology, Protein misfolding and aggregation, Protein Engineering


Evaluating anti-amyloid genic propensity of surface functionalized carbon dots.


 Principal Investigator

 36 months



Stability, mutagenesis and functional studies on Fibroblas Growth Factor Homologous Factors (RGYI)


 Principal Investigator

 36 months



 Continuing Education

National Bioengineering Conference (NBC) 2023 : Bioengineering in Healthcare, Environment and Agriculture

 Biotechnology and Medical Engineering


 09 Nov 2023 - 11 Nov 2023




Google Scholar h-index


Google Scholar i10-index


Scopus h-index

Total Publications: 34
M. T. Prabhu, S. Chrungoo, and N. Sarkar, "Amine Group Surface-Functionalized Carbon Quantum Dots Exhibit Anti-amyloidogenic Effects Towards Hen Egg White Lysozyme by Inducing Formation of Nontoxic Spherical Aggregates", The Protein Journal, Springer, October 2023, 10.1007/s10930-023-10157-x Article
A. Mukherjee and N. Sarkar, "A facile one pot synthesis of water-soluble CQDs for evaluation of their anti-amyloidogenic propensity", Materials Advances, vol.4, pp.2106-2118, RSC, March 2023, 10.1039/D2MA01041K Article
B. Halder, A. Mitra, S. Dewangan, R. Gazi, N. Sarkar, M. Jana, and S. Chatterjee, "Solid state synthesis of bispyridyl-ferrocene conjugates with unusual site selective 1,4-Michael addition, as potential inhibitor and electrochemical probe for fibrillation in amyloidogenic protein", Journal of Molecular Structure, vol.1273, no.134362, Elsevier, February 2023, 10.1016/j.molstruc.2022.134362 Article
A. Mitra, A. Mitra, and N. Sarkar, "Differential effects of DTT on HEWL amyloid fibrillation and fibril morphology at different pH", Biophysical Chemistry, Elsevier, January 2023, 10.1016/j.bpc.2023.106962 Article
A. Mitra and N. Sarkar, "Elucidating the inhibitory effects of rationally designed novel hexapeptide against hen egg white lysozyme fibrillation at acidic and physiological pH", BBA Proteins and Proteomics, Elsevier, January 2023, 10.1016/j.bbapap.2023.140899 Article

Show All Publications(+)

D. Chakraborty, A. Mukherjee, and N. Sarkar, "A Comprehensive Review on Inorganic Nanoparticles as Effective Modulators of Amyloidogenesis", Protein and Peptide Letters, Bentham Science 2023, 10.2174/0929866530666230705153229 Article
K. Kundal, S. P, A. Mitra, and N. Sarkar, "dentification of Novel Peptides as Potential Modulators of Aß42 Amyloidogenesis: An insilico Approach", Current Computer-Aided Drug Design, Bentham Science 2023, 10.2174/1573409919666230112170012 Article
P. Seth and N. Sarkar, "A comprehensive mini-review on amyloidogenesis of different SARS-CoV-2 proteins and its effect on amyloid formation in various host proteins", 3 Biotech, vol.12, no.11, pp.322, Springer, November 2022, 10.1007/s13205-022-03390-1 Article
A. Mukherjee and N. Sarkar, "Recent Developments in Quantum Dots Technologies as Effective Theranostic Tools Against Cancer", Application of Quantum Dots in Biology and Medicine, ch.18, pp.103-123, Springer, October 2022, 10.1007/978-981-19-3144-4_6 Inbook
A. Das, M. T. Prabhu, and N. Sarkar, "Synthesis, characterization, and in vitro DPPH radical scavenging assay study of PEG-capped carbon nanoparticles derived from Butea monosperma flower extract", Advances in Natural Sciences: Nanoscience and Nanotechnology, vol.13, no.015002, IOP Science, February 2022, 10.1088/2043-6262/ac5498 Article
M. T. Prabhu and N. Sarkar, "Inhibitory effects of carbon quantum dots towards hen egg white lysozyme amyloidogenesis through formation of a stable protein complex", Biophysical Chemistry, Elsevier 2022, 10.1016/j.bpc.2021.106714 Article
M. T. Prabhu and N. Sarkar, "Surface Modified Carbon Quantum Dots as therapeutic agents against amyloidosis", in International Conference in Biotechnology for Resource Efficiency, Energy, Environment, Chemicals and Health, December 2021 Inproceedings
A. Mitra and N. Sarkar, "The role of intra and inter-molecular disulfide bonds in modulating amyloidogenesis: A review", Archives of Biochemistry and Biophysics, vol.716, no.109113, Elsevier, December 2021, 10.1016/ Article
S. P, K. Kundal, and N. Sarkar, "Human Serum Albumin aggregation and its modulation using nanoparticles: A review", Protein and Peptide Letters, Bentham Science, November 2021, 10.2174/0929866528666211125104600 Article
N. Sarkar, "Functional amyloids", Biopolymer-Based Formulations: Biomedical and Food Applications, ch.12, pp.263-282, Elsevier, January 2020, 10.1016/B978-0-12-816897-4.00012-6 Inbook
H. Mandal, A. Basak, M. T. Prabhu, V. Kolli, and N. Sarkar, "Inhibitory as well as Disaggregation Potential of Selected Hydroxy Benzoic Phytochemicals on Hen Egg-White Lysozyme Amyloidogenesis", Current Proteomics, Bentham Science 2020, 10.2174/1570164617999200729161846 Article
A. Mitra and N. Sarkar, "Sequence and structure-based peptides as potent amyloid inhibitors: A review", Archives of biochemistry and biophysics, Elsevier 2020, 10.1016/ Article
V. Kolli, S. Paul, P. K. Guttula, and N. Sarkar, "Elucidating the role of Val-Asn 95 and Arg-Gly 52 mutations on structure and stability of fibroblast growth factor homologous factor 2", Protein and Peptide Letters, vol.26, no.12, Bentham Science 2019, 10.2174/0929866526666190503092718 Article
N. Sarkar, "Proline capped gold nanoparticle mediated inhibition of hen egg white lysozyme amyloidogenesis", in Recent Advances in Biochemical Engineering and Biotechnology 2019 2019 Inproceedings
S. Karmakar, N. Sarkar, and L. Pandey, "Proline functionalized gold nanoparticles modulates lysozyme fibrillation", Colloids and Surfaces B: Biointerfaces, vol.174, pp.401-408, Elsevier 2019, 10.1016/j.colsurfb.2018.11.032 Article
N. Sarkar, "Studies on effects of selected phytochemicals on Hen Egg white lysozyme Amyloidogenesis", in 14th Asian Congress of Biotechnology 2019, Taipei, Taiwan 2019 Inproceedings
M. T. Prabhu and N. Sarkar, "Quantum dots as promising theranostic tools against amyloidosis: a review", Protein and Peptide Letters, vol.26, no.12, Bentham Science 2018, 10.2174/0929866526666181212113855 Article
P. Paul, N. Sarkar, and I. Banerjee, "Effect of grapheme oxide on hen egg white lysozyme amyloidogenesis", December 2017 Proceedings
T. Das, V. Kolli, S. Karmakar, and N. Sarkar, "Functionalisation of polyvinylpyrrolidone on gold nanoparticles enhances its anti-amyloidogenic Propensity towards hen egg white lysozyme", Biomedicines, vol.5, no.2, MDPI, May 2017, 10.3390/biomedicines5020019 Article
R. Chatterjee, V. Kolli, and N. Sarkar, "Trehalose and magnesium chloride exert a common anti-amyloidogenic effect towards hen egg white lysozyme", The Protein Journal, vol.36, no.2, pp.138-146, Springer, December 2017, 10.1007/s10930-017-9705-2 Article
V. Kolli and N. Sarkar, "Role of Val-Asn95 and Arg-Gly 52 mutations on the thermodynamic stability of fibroblast growth factors homologous factor 2", in 23rd meeting of the International Network of Protein Engineering Centers 2017 Inproceedings
V. Kolli, S. Paul, and N. Sarkar, "An overview on fibroblast growth factors: Structural, functional and therapeutic implications", Current Proteomics, vol.12, no.3, pp.144-151, Bentham Science, December 2016, 10.2174/157016461203151120093251 Article
A. Evr, K. Krishnan, A. Maurya, and N. Sarkar, "In silico screening of drugs to find potential gamma-secretase inhibitors using pharmacophore modeling, QSAR and molecular docking studies", Combinatorial Chemistry and High Throughput Screening, vol.17, no.9, pp.770-780, Bentham Science Publishers B.V., December 2014, 10.2174/1386207317666141019195448 Article
N. Sarkar and V. K. Dubey, "Exploring critical determinants of protein amyloidogenesis: a review", Journal of Peptide Science, vol.19, no.9, pp.529-536, Wiley, September 2013, 10.1002/psc.2539 Article
M. Kumar, N. Sarkar, and V. Dubey, "Evaluating quinacrine as a potential amyloid imaging compound: studies on hen egg white lysozyme as model system", Protein and Peptide Letters, vol.19, no.8, pp.826-831, Bentham Science, December 2012, 10.2174/092986612801619598 Article
N. Sarkar, M. Kumar, and V. K. Dubey, "Effect of sodium tetrathionate on amyloid fibril: Insight in to the role of disulfide bond in amyloid progression", Biochimie, vol.93, no.5, pp.962-968, NCBI 2011, 10.1016/j.biochi.2011.02.006 Article
N. Sarkar, M. Kumar, and V. K. Dubey, "Rottlerin dissolves pre-formed protein amyloid: A study on hen egg white lysozyme", Biochimica et Biophysica Acta - General Subjects, vol.1810, no.9, pp.809-814, Elsevier 2011, 10.1016/j.bbagen.2011.06.012 Article
N. Sarkar, A. N. Singh, and V. K. Dubey, "Effect of curcumin on amyloidogenic property of molten globule like intermediate state of 2,5-Diketo-D-Gluconate Reductase A.", Biological Chemistry, vol.390, De Gruyter 2009, 10.1515/BC.2009.107 Article
N. Sarkar, P. K. Srivastava, and V. K. Dubey, "Understanding the language of Vitamin C", Current Nutrition & Food Science, vol.5, no.1, pp.53-55(3), Bentham Science 2009, 10.2174/157340109787314767 Article

 Courses Taught

  • BM2007 : Biochemistry {Theory}
  • BM2101 : Cell and Molecular Biology {Theory}
  • BM241 : Biotechnology in Human Health {Theory}
  • BM251 : Bioprocess Calculation {Theory}
  • BM254 : Bioprocess Calculation {Theory}
  • BM342 : Industrial Microbiology {Theory}
  • BM351 : Genetic Engineering {Theory}
  • BM403 : Medical Biotechnology {Theory}
  • BM441 : Protein Engineering {Theory}
  • BM442 : Structural Biology {Theory}
  • BM443 : Introduction to Biotechnology {Theory}
  • BM444 : Introduction to Molecular Medicine {Theory}
  • BM444 : Structural Biology {Theory}
  • BM461 : Protein Engineering {Theory}
  • BM6402 : Advanced Protein Engineering {Theory}
  • BM643 : Advanced Protien Engineering {Theory}
  • BM650 : Industrial Microbiology {Theory}
  • BM653 : Protein Engineering {Theory}
  • BM654 : Advanced Bioseparation {Theory}
  • BM2703 : Biochemistry and Microbiology Laboratory {Practical}
  • BM274 : Analytical Biotechnology Laboratory {Practical}
  • BM274 : Bioheat and Mass Transfer Laboratory {Practical}
  • BM282 : Microbiology Laboratory {Practical}
  • BM372 : Bioseparation Laboratory {Practical}
  • BM381 : Industrial Microbiology Laboratory {Practical}
  • BM382 : Cell and Molecular Biology Laboratory {Practical}
  • BM4709 : Enzymology and Protein Engineering Laboratory {Practical}
  • BM472 : Bioseparation Laboratory {Practical}
  • BM6471 : Advanced Cell and Molecular Engineering Laboratory {Practical}
  • BM671 : Advanced Bioseparation Laboratory {Practical}
  • BM672 : Advanced Bioseparation Laboratory {Practical}
  • BM673 : Cell and Protein Processing Laboratory {Practical}

 Research Scholars

Ph.D. Students [4]
Mutagenesis, Structure, Stability and in silico Studies on Fibroblast Growth Factor Homologous Factor 2

 Vidyalatha Kolli

Enrolled: Mar 2014

 Graduated : Jun 2021


Studies on the effects of surface functionalized carbon quantum dots towards hen egg white lysozyme amyloidogenesis

 Macherla Pochaiah Taraka Prabhu

Enrolled: Aug 2017

 Thesis Submitted : Jun 2023


Protein Biochemistry

 Amit Mitra

Enrolled: Jul 2019



Effect of Organic - Inorganic Coreshell Nanoparticles on the Modulation and Detection of Model Amyloids

 Debashmita Chakraborty

Enrolled: Aug 2021




PG Dissertation
  • Gloria Narayan (214BM2028), "Mutagenesis, Expression and Purification of mutant form of Fibroblast growth factor homologous factor 1 (FHF1)" - M.Tech.    Supervisor     2015-16 Spring
  • Rupsa Chatterjee (214BM2023), "Study of Effect of Selected Compounds on Hen Egg White Lysozyme (HEWL) Amyloidogenesis" - M.Tech.    Supervisor     2015-16 Spring
  • Tulika Das (214BM2019), "Effect of Polyvinylpyrrolidone (PVP) functionalized gold nanoparticles on hen Egg-white lysozyme (HEWL) amyloids: An inhibition and disaggregation study" - M.Tech.    Supervisor     2015-16 Spring
  • Srijeeb Karmakar (215BM2256), "Studies on Effect of Proline Capped Gold Nanoparticles on Hen Egg White Lysozyme (HEWL) and Cytochrome C (Cyt C) Amyloidogenesis" - M.Tech.    Supervisor     2016-17 Spring
  • Pritha Paul (216BM2019), "Self-assembled cytochrome c microaggregates: A novel functional moiety for biomedical application" - M.Tech.    Supervisor     2017-18 Spring
  • Arbin Basak (217BM2425), "Studies on effects of vanillic and iso-vanillic acid on Hen Egg White Lysozyme(HEWL) amyloidogenesis" - M.Tech.    Co-supervisor     2018-19 Spring
  • Hitesh Mandal (217BM2013), "Studies on effects of gallic acid and syringic acid on Hen Egg White Lysozyme (HEWL) Amyloidogenesis" - M.Tech.    Supervisor     2018-19 Spring
  • Reshob Routh (218BM2010), "Studies on Effect of Polar and Non-Polar Amino Acid Derived Carbon Quantum Dots on Hen Egg White Lysozyme (HEWL) Fibrillation" - M.Tech.    Supervisor     2019-20 Spring
  • Kavita Kundal (219BM2424), "In Silico identification of novel peptides as a potential inhibitor of Aß42 Amyloidogenesis" - M.Tech.    Supervisor     2020-21 Spring
  • Santhosh P (219BM2018), "Docking and Simulation analysis of nanoparticles interactions with Bovine Serum Albumin" - M.Tech.    Supervisor     2020-21 Spring
  • Aranyak Mitra (220BM2208), "Deciphering the role of disulfide bond on the stability, amyloid fibrillation propensity and fibril morphology of Hen Egg White Lysozyme (HEWL)" - M.Tech.    Supervisor     2021-22 Spring
  • Prakriti Seth (221BM2168), "Synthesis and Characterisation of Amyloid-based Hydrogels using different Gelation Agents: A potential tool for Drug Delivery" - M.Tech.    Supervisor     2022-23 Spring
UG Dissertation
  • Ajeet Singh (111BT0590), "Identification of drug target against Bacteroides fragilis 638R: through Insilico genome analysis" - B.Tech.    Supervisor     2014-15 Spring
  • Om Bikash Kumar Das (111BT0571), "Identification of a novel drug target protein against Haemophilus influenzae Rd KW20: an insilico approach" - B.Tech.    Supervisor     2014-15 Spring
  • Sudipt Kumar Dalei (112BT0017), "In silico drug targetting against the enzyme D-sedohepulose-7-phosphate isomerase of the bacteria ‘Pseudomonas Aeruginosa’" - B.Tech.    Supervisor     2015-16 Spring
  • Megha Agarwal (114BT0294), "In Silico prediction of antimalarial drug target candidates against Plasmodium falciparum" - B.Tech.    Supervisor     2017-18 Spring
  • Satyam Ahirwar (114BT0597), "Study of Effect of Selected Ions on Hen Egg White Lysozyme (HEWL) Amyloidogenesis" - B.Tech.    Supervisor     2017-18 Spring
  • Shibu Prasad Behera (113BT0017), "Effect of Selected Amino Acids On HEWL Amyloidgenesis" - B.Tech.    Supervisor     2017-18 Spring
  • Siddharth Kumar (115BT0622), "STUDIES ON METAL DETECTION BY CARBON QUANTUM DOTS DERIVED FROM ASOCA LEAVES" - B.Tech.    Supervisor     2018-19 Spring
  • Apoorva Potnuru (116BT0043), "STUDIES on NITROGEN DOPED CARBON QUANTUM DOTS derived from GLUCOSE and UREA" - B.Tech.    Supervisor     2019-20 Spring
  • G V Nikhil (116BT0039), "STUDIES ON BISCUIT POWDER DERIVED PHOSPHORUS DOPED CARBON QUANTUM DOTS" - B.Tech.    Supervisor     2019-20 Spring
  • Arijit Das (116BT0029), "Synthesis, Characterization and In vitro Antioxidation Activity Study of PEG400-capped Carbon Nanostructures Derived from B. monosperma Floral Extract" - B.Tech.    Supervisor     2020-21 Spring
  • Sunkara Neeharika (117BT0032), "In silico Docking of various Ligands with a a-calcitonin gene-related peptide (CGRP) receptor – a target protein for migraine using AutoDock" - B.Tech.    Supervisor     2020-21 Spring
  • Ananya Rout (118BT0023), "IN SILICO IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST P300 ACETYLTRANSFERASE" - B.Tech.    Supervisor     2021-22 Spring
  • Gadde Lakshman Pavan Kumar (118BT0650), "In silico studies on identification of potential inhibitors against alpha-synuclein aggregation" - B.Tech.    Supervisor     2021-22 Spring
  • Ekta Kumari (119BT0435), "Amyloid Based Hydrogel derived from Hen Egg White Lysozyme(HEWL) and Tris(2-Carboxyethyl) phosphine(TCEP) : A potential constituent for Biomedical applications." - B.Tech.    Supervisor     2022-23 Spring
  • Koneru Hemesh (119BT0807), "Green Synthesis of Silver Nanoparticles (using Lemon fruit extract) and Its Effects on Amyloid Formation" - B.Tech.    Supervisor     2022-23 Spring
  • Olivia Neibel Isaac Newton (119BT0433), "STUDYING THE EFFECT OF ZINC AS AN ANTIDEPRESSANT IN ZEBRAFISH MODEL" - B.Tech.    Co-supervisor     2022-23 Spring

 Awards and Honours

Awards and Honours
  • Editorial Board Member, Protein and Peptide Letters, Bentham Science Publications,    2016
  • Received Young Scientist Program Award for 21st International Union of Biochemistry and Molecular Biology (IUBMB) and 12th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) International Congress of Biochemistry and Molecular Biology held in China,    2009
  • Awarded International Union of Biochemistry and Molecular Biology (IUBMB) full travel fellowship to attend the 21st IUBMB and 12th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) International Congress of Biochemistry and Molecular Biology held in China,    2009
  • Received B.S Narasinga Rao Best Poster presentation Award during 77th Annual Meeting of Society of Biological Chemists held in Chennai,    2008
  • Qualified Graduate Aptitude Test in Engineering (GATE) 2007 in Life Sciences with a percentile of 98.39 and All India Rank of 175,    2007
Memberships / Fellowships
  • NABS,    2018
  • ISCB,    2018
  • BRSI,    2018
  • SBCI,    2009